重组人Bcl-2北京品牌

特别提示：包括重组人Bcl-2在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人Bcl-2
英文名称：Recombinant Human B-cell Lymphoma 2
产品货号：GS4905
产品规格：5μg

分子量：Approximately 23.2kDa,a single non-glycosylated polypeptide chain containing 210 amino acids.
储存条件：冷冻（-20℃）

概述

B-cell lymphoma 2(Bcl-2)is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human.Bcl-2
forms homodimer and heterodimers with other Bcl-2 family proteins,like BAX,BAK,BAD and Bcl-xL.Alternative splicing of
Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity.Bcl-2 suppresses apoptosis by
controlling the mitochondrial membrane permeability.It inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1).Antibodies to Bcl-2 can be used with
immunohistochemistry to identify cells containing the antigen.In some cases,the presence or absence of Bcl-2 staining in
biopsies may be significant for the patients prognosis or likelihood of cancer relapse.Mature human Bcl-2 shares 88%- 90%
amino acid sequence identity with murine,rat,bovine,canine Bcl-2.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further
evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile liquid.
Purity:	＞95%by SDS-PAGE and HPLC analyses.
Source:	Escherichia coli.
Biological Activity:	Test in Process.
Formulation:	0.2μmfiltered concentrated solution in 25mMTris-HCl,pH 8.0,100mM NaCl,1 mM DTT,30% Glycerol,with Tween-80.
内毒素	Less than 0.1 EU/μg of rHuBcl-2 as determined by LAL method.
氨基酸序列	AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD

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