重组人BMP-4北京供应商

特别提示：包括重组人BMP-4在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人BMP-4
英文名称：Recombinant Human Bone Morphogenetic Protein 4
产品货号：GS4848
产品规格：2μg

分子量：Approximately 13.3kDa,a monomeric,non-glycosylated polypeptide chain containing 117 amino acids.
储存条件：冷冻（-20℃）

概述

Bone Morphogenetic Protein 4 is one of the BMPs,some of which belong to the TGF-beta superfamily(BMP2-7).There are more than thirteen BMPs have been discovered nowadays and they are involved in inducing cartilage and bone formation.BMP-4 is expressed in the lung and lower levels seen in the kidney.It also presents in normal and neoplastic prostate tissues,and prostate cancer cell lines.It regulates the formation of teeth,limbs and bone from mesoderm.Furthermore it also plays a role in fracture repair.BMP-4 signals through tetrameric complexes composed of type I and type II receptors and regulates it function by interaction with multiple proteins and glycosaminoglycans.The human BMP-4 shares 98%sequence indentity with mouse BMP-4.Reduced expression of BMP-4 is associated with a number of bone diseases,including the heritable disorder Fibrodysplasia Ossificans Progressiva.

应用

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

使用说明

This lyophilized preparation is stable at 2-8 ℃,but should be kept at -20 ℃ for long term storage,preferably desiccated.Upon reconstitution,the preparation is stable for up to one week at 2-8 ℃.For maximal stability,apportion the reconstituted pr

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Data is not available.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 50mMNa2CO3,5 mM DTT,pH 11.0.
内毒素	Less than 1 EU/μg of rHuBMP-4 as determined by LAL method.
复溶	1.Molecular standard(Western,ELISA)in studying secreted BMP-4;2.Preparing antibodies for BMP-4 monomer;3.Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE.
氨基酸序列	MSPKHHSQRA RKKNKNCRRH SLYVDFSDVG WNDWIVAPPG YQAFYCHGDC PFPLADHLNS TNHAIVQTLV NSVNSSIPKA CCVPTELSAI SMLYLDEYDK VVLKNYQEMV VEGCGCR

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