重组人IL-1RA北京现货

特别提示：包括重组人IL-1RA在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-1RA
英文名称：Recombinant Human Interleukin-1 Receptor Antagonist
产品货号：GS4818
产品规格：20μg

分子量：Approximately 17.1kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-1 receptor antagonist(IL-1RA)is a member of the IL-1 family.IL-1RA is secreted by various types of cells including immune cells,epithelial cells,and adipocytes,and is a natural inhibitor of the pro-inflammatory effect of IL-1β.This protein inhibits the activities of interleukin 1,alpha(IL-1α)and interleukin 1,beta(IL-1β),and modulates a variety of interleukin 1 related immune and inflammatory responses.IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-RA.The regulated expression of IL-1RA in various cell types has been shown to be influenced by cytokines.In synovial fibroblasts the synthesis of IL-1RA is markedly enhanced by IL-1,TNF-α,or PDGF.The protein shows 26%amino acid homology to IL-1β and 19%homology to IL-1α.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞96%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 40ng/ml,corresponding to a specific activity of>2.5×104 IU/mg in the presence of 50pg/ml rHuIL-1α.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-1RA as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE

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