重组人趋化因子CXCL4(PF4)北京厂家

特别提示：包括重组人趋化因子CXCL4(PF4)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人趋化因子CXCL4(PF4)
英文名称：Recombinant Human C-X-C Motif Chemokine 4
产品货号：JN028jiǔ
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备，目的基因编码的Glu32-Ser101表达纯化而来。

CXCL4/PF4质量控制：＞95%(还原性SDS-PAGE)。

CXCL4/PF4制剂：冻干品

CXCL4/PF4保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CXCL4/PF4复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CXCL4/PF4：
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 6sì% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.

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