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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
263707-16-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥710.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥1050.0 |
| 规格： | 25 mg | 产品价格： | ￥2080.0 |
| 规格： | 50 mg | 产品价格： | ￥3560.0 |
| 规格： | 100 mg | 产品价格： | ￥5500.0 |
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ESI-09
CAS No. : 263707-16-0
MCE 国际站：ESI-09
产品活性：ESI-09是新型非环状核苷酸EPAC的拮抗剂，抑制EPAC1 and EPAC2的IC50值分别为3.2和1.4 μM。
研究领域：Anti-infection
作用靶点：Virus Protease
In Vitro: While cAMP competes with 8-NBD-cAMP binding with an IC50 of 39 μM, ESI-09 shows an increased potency with an apparent IC50 of 10 μM. ESI-09 inhibis cAMP-mediated EPAC2 and EPAC1 GEF activity with an IC50 of 1.4 and 3.2μM, respectively. ESI-09 could fit well into the functional cAMP-binding pocket of EPAC1, establishing favorable hydrophobic and hydrogen bonding interactions with the protein’s active-site residues. ESI-09 inhibits 007-AM-stimulated Akt phosphorylation at T308 and S473 in a dose-dependent manner. ESI-09 inhibits pancreatic cancer cells AsPC-1 and PANC-1 migration. ESI-09 inhibits EPAC1-mediated adhesion of PDA cells on collagen I. Exposure to ESI-09 significantly reduces intracellular and total bacterial counts in HUVECs at 30 min postinfection with 10 multiplicities of infection (MOI) of R. australis compared with similarly infected controls.
In Vivo: Treatment with ESI-09 dramatically protects WT mice against R. australis infection with much milder disease manifestations and significantly improves survival.
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文献和实验36 4.09 3.50 3.17 2.94 2.78 2.66 2.57 2.49 2.43 2.33 2.22 2.11 1.99 1.85 1.69 36 37 4.08 3.49 3.16 2.93 2.77 2.65 2.56 2.48 2.42 2.32 2.21 2.10 1.97 1.84 1.67 37 38 4.07 3.48 3.14 2.92 2.76 2.64 2.55 2.47 2.41 2.31 2.20 2.09 1.96 1.82 1.66 38
电喷雾离子化质谱法（ESI/MS）可对酵母细胞中全部脂质进行鉴定和定量分析。此方法无需对酵母细胞脂质进行层析分离，可分析低至g/ml浓度的脂质。 0:05 电喷雾离子化质谱法定量分析酵母脂质组5 0:21 内容订阅21 0:49 内容简介49 1:09 提取酵母脂质69 5:26 脂质分析326 7:48 脂质质谱分析结果468 8:05 结论485 电喷雾离子化质谱法定量分析酵母脂质组本视频来源于网络，如有异议请联系我们，我们将在5个工作日内作出处理。
:35 Etag: "6d3d3d0e-7-2248324-4769a283" 2008-01-04 16:07:35 Last-modified: Wed, 19 Dec 2007 23:00:19 GMT 2008-01-04 16:07:35 Accept-ranges: bytes 2008-01-04 16:07:35 Connection: close 2008-01-04 16:07:35 开始读取数据... 2008-01-04 16:09:34 读取数据发生错误
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