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- 文献和实验
- 技术资料
- 抗体名:
APC Anti-Mouse IL-10 Antibody流式抗体[JES5-16E3]_货号:E-AB-F1197UE
- 抗体英文名:
APC Anti-Mouse IL-10 Antibody[JES5-16E3]_货号:E-AB-F1197UE
- 应用范围:
ICFCM
- 宿主:
Rat
- 适应物种:
Mouse
- 保质期:
12个月
- 目录编号:
E-AB-F1197UE
- 级别:
科研
- 库存:
999
- 供应商:
武汉伊莱瑞特生物科技股份有限公司
- 标记物:
APC
- 克隆性:
Monoclonal
- 保存条件:
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
- 形态:
液体
- 亚型:
Rat IgG2b, κ
- 规格:
100μg/25μg
| 规格: | 100μg | 产品价格: | ¥2736.0 |
|---|---|---|---|
| 规格: | 25μg | 产品价格: | ¥1032.0 |
货号:E-AB-F1197UE
| Background |
L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. IL-10 inhibits IFN-γ, TNF-β, and IL-2 production by Th1 clones; inhibits macrophage-mediated IL-1, IL-6, and TNF-α synthesis; suppresses the delayed type hypersensitivity response; stimulates Th2 cell response (which results in elevated antibody production); and promotes mast cell proliferation in combination with IL-4.
|
| Alternate Names |
Interleukin-10;IL-10;Cytokine synthesis inhibitory factor;CSIF;
|
| Swissprot |
P18893
|
| Gene ID |
16153
|
| Clone No |
JES5-16E3
|
| Host |
Rat
|
| Reactivity |
Mouse
|
| Application |
ICFCM
|
| Isotype |
Rat IgG2b, κ
|
| Isotype Control |
APC Rat IgG2b, κ Isotype Control[LTF-2]
|
| Conjugation |
APC
|
| Conjugation Information |
APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter).
|
| Storage Buffer |
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
|
| Storage |
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
|
| Expiration date |
12个月
|
| Shipping |
冰袋
|
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文献和实验自2012年第一篇引用文献问世,至2023年8月,Elabscience已协助各地科研工作者发表超13,000篇SCI文献,包括行业顶/级期刊Nature Medicine, Nature, Cell, Signal Transduction and Targeted Therapy, Circulation, Molecular Cancer, Immunity, Advanced Materials等,总影响因子(IF)59472.59,其中IF≥30的文献超30篇,最高影响因子为66.849,发文单位包含北京大学、中国科学技术大学、浙江大学、斯坦福大学、耶鲁大学、柏林夏里特大学等国内外各大高校。
每年引用文献数量持续增长,保持逐年30%+高增长率,可以预见,Elabscience产品将帮助更多科研工作者发表高质量SCI论文。
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10%的DMSO到加尾反应中去,而2.8kb的TSC-2 cDNA(图3)和APC产物(图2)可以很容易加尾和扩增,不需另外添加DMSO。 当在5′RACE中使用DMSO时,应该考虑DMSO对随后的PCR的影响,在这项研究中,用于扩增的少量加尾反应物(50ml PCR体系中加1ml),能够使所用的DNA聚合酶的任何潜在的抑制作用最小化,如果目标cDNA的有效加尾,需要DMSO,加尾的cDNA在扩增前,通过纯化,去掉DMSO,可以消除任何潜在的对PCR抑制作用。 结论 这项研究结果显示
suspension. 5) Label another sample tube for each fluorochrome-conjugated antibody you are using, and add 1 drop of AbC™ capture beads (Component A in the AbC™ Anti-Mouse Bead Kit) to each tube. 6) Add a pre-titrated
来瓶「红牛」继续干!唐力团队发现 IL-10 可激活终末耗竭 T 细胞,为增强肿瘤免疫治疗提供新思路
exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity 的研究成果。该研究发现,IL-10 通过上调线粒体丙酮酸载体依赖的氧化磷酸化,从而介导 T 细胞代谢重编程,进而恢复终末耗竭 T 细胞的活力,并增强癌症免疫治疗的反应。 图片来源:Nature Immunology研究内容IL-10 直接扩增终末耗竭的 CD8 + 细胞作者首先制备了重组的人 IL-10 和 IgG1 Fc 的融合蛋白(IL-10–Fc),该蛋白可以与小鼠 IL-10 受体
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