Acadesine(2627-69-2)(≥98%)

特别提示：包括Acadesine在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：Acadesine
英文名称：Acadesine
产品货号：L10091
产品规格：50mg|250mg|1g
 

属性

CAS号	2627-69-2
分子式	C9H14N4O5
分子量	258.23
溶解性	Soluble in water(9mg/ml),and DMSO(75mM).
存贮条件	储存温度-20℃

描述

应用	An inhibitor of the transcription of PPARα,the coactivation of PPARα.
产品介绍	Acadesine导致ZMP的积累，Acadesine模仿AMP对AMPK和AMPK的刺激作用。
备注	Acadesine results in accumulation of ZMP,which mimics the stimulating effect of AMP onAMPKandAMPK.Phase 3.
生化机理	AICAR(AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha.In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research.Additionally,research indicates that AICAR blocks the differentiation of 3T3-L1(sc-2243) adipocytes.Studies demonstrate that AICAR can mimic the activity of insulin by activating AMPK(AMP-activated protein kinase),and affecting the expression of PEPCK-M(PEPCK) and glucose-6-phosphatase(G6Pase).The 5-aminoimidazole-4-carboxamide ribonucleoside(ZMP) is the monophosphorylated derivative of AICA-Riboside,and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase(ATIC).AICAR is an inhibitor of Hsp90,mTOR and p70 S6 Kinase.
别名	阿卡地新;5-氨基-1-beta-D-fū喃核糖基-1H-咪唑-4-甲酰胺;AICAR;5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide;5-Aminoimidazole-4-carboxamide;1-β-D-ribofuranoside;N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

我公司销售的Acadesine(2627-69-2)(≥98%)，5-Aminoimidazole-4-carboxamide，N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide，5-氨基-1-beta-D-fū喃核糖基-1H-咪唑-4-甲酰胺，1-β-D-ribofuranoside，AICAR，阿卡地新，5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide质量上佳，价格普惠，欢迎广大新老客户踊跃订购。