Sinapinic acid芥子酸,530-59-6

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Sinapinic acid

CAS No. : 530-59-6

MCE 国际站：Sinapinic acid

产品活性：Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物，为 HDAC 的抑制剂，IC₅₀ 值 2.27 mM，对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性，诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化、抗糖尿病的作用。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数，并使抗氧化能力和氧化损伤的一些血清参数正常化。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation  |  Apoptosis

作用靶点：HDAC  |  Angiotensin-converting Enzyme (ACE)  |  Reactive Oxygen Species  |  Apoptosis

In Vitro: Sinapinic acid acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM. Sinapinic acid also inhibits ACE-I activity.
?Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC₅₀s of 0.91 ± 0.02 mM and 1.6?±?0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells.

In Vivo: Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats.

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