2,5-Dihydroxybenzoic acid2,5-二

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2,5-Dihydroxybenzoic acid

CAS No. : 490-79-9

MCE 国际站：2,5-Dihydroxybenzoic acid

产品活性：2,5-Dihydroxybenzoic acid 是苯甲酸的代谢物，也是纤维母细胞生长因子 (fibroblast growth factor) 的强效抑制剂。

研究领域：Metabolic Enzyme/Protease  |  Protein Tyrosine Kinase/RTK

作用靶点：Endogenous Metabolite  |  FGFR

结构分类：酚类  |  多酚类  |  酮、醛、酸

In Vitro: 2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis.

In Vivo: It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases.

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