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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Hydrocoumarin; Chroman-2-one
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
119-84-6
- 规格：
10 mM * 1 mL/10 g/25 g/50 g/100 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥110.0 |
|---|---|---|---|
| 规格： | 10 g | 产品价格： | ￥100.0 |
| 规格： | 25 g | 产品价格： | ￥145.0 |
| 规格： | 50 g | 产品价格： | ￥185.0 |
| 规格： | 100 g | 产品价格： | ￥245.0 |
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Dihydrocoumarin
CAS No. : 119-84-6
MCE 国际站：Dihydrocoumarin
产品活性：Dihydrocoumarin 是在 Melilotus officinalis 中发现的一种化合物。Dihydrocoumarin 是酵母 Sir2p 抑制剂。 Dihydrocoumarin 还抑制人 SIRT1 和 SIRT2，IC 50 分别为 208 μM 和 295 μM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：Sirtuin
In Vitro: Dihydrocoumarin induces a concentration-dependent inhibition of SIRT1 (IC50 of 208 μM) in an in vitro enzymatic assay. A decrease in SIRT1 deacetylase activity is observed even at micromolar doses (85±5.8 and 73±13.7% activity at 1.6 μM and 8 μM, respectively). The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM).
Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. A 5-mM dose of Dihydrocoumarin increases apoptosis at the 6-h time point in the TK6 cell line.
Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period.
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文献和实验4.908g 9.815g 14.723g H2 O mQ 90.62 47.42ml 94.84ml 142.3ml Conc. Stock %(w/w) 50ml 100ml 150ml KC2 H3 O2 5M 98.15g/M 40.29 24.54g 49.08g 73.61g H2 O mQ 59.71
，平均年龄(64.5±4)岁:①尿蛋白定性检查阴性患者210例，其中糠尿病56例，高血压58例，腔隙性脑梗塞42例，冠心病54例。②尿蛋白定性阳性患者119例，肾炎41例，肾病32例，糖尿病28例，高血压18例。③对照组48例，系健康体检人群，男22例，女26例，平均年龄(64.5±3)岁。 1.2 仪器 意大利产半自动生化分析仪，型号ENZI PHOTOMETER640 1.3 试剂和方法 尿NAG检测用终点法，试剂由天津南新高科技实业公司提供。尿肌酐测定，苦味酸法，试剂
参数 动物种胆红素 mg%胆固醇 mg%肌酐 mg%葡萄糖 mg%尿素氮 mg%尿酸 mg%钠 mEg/l钾 mEg/l氯 mEg/l重碳酸盐 mEg/l无机磷 mg%钙 mg%镁 mg%小鼠0.75±0.050.60±0.04(0.10-0.90)63.3±11.865.5±21.1(26.0-82.4)0.84±0.190.67±0.17(0.30-1.00)92.2±10.585.0±9.50(62.8-176)20.8±5.8617.9±4.50(13.9-28.3)4.12±
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