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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Dan shen suan A; Salvianic acid A
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
76822-21-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥288.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥132.0 |
| 规格： | 5 mg | 产品价格： | ￥330.0 |
| 规格： | 10 mg | 产品价格： | ￥550.0 |
| 规格： | 25 mg | 产品价格： | ￥904.0 |
| 规格： | 50 mg | 产品价格： | ￥1200.0 |
| 规格： | 100 mg | 产品价格： | ￥1800.0 |
| 规格： | 200 mg | 产品价格： | ￥2775.0 |
| 规格： | 500 mg | 产品价格： | ￥4650.0 |
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Danshensu
CAS No. : 76822-21-4
MCE 国际站：Danshensu
产品活性：Danshensu 是丹参的有效成分，能够激活 Nrf2 信号通路，保护心血管。
研究领域：NF-κB | Autophagy | Apoptosis
作用靶点：Keap1-Nrf2 | Autophagy | Apoptosis
In Vitro: Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis.
In Vivo: Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway.
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文献和实验［3］ 黄喜茹, 范桂敏, 冯媛媛, 等. 复方丹参制剂质量控制研究［J］. 时珍国医国药, 2006, 17(9): 1628�1629. ［4］ 余孝东. 安神口服液的质量控制研究［J］. 医药论坛杂志, 2003, 24(20): 21�22. ［5］ 黄喜茹, 曹 冬, 刘振通, 等. RP�HPLC法测定丹参饮片中丹参素和原儿茶醛［J］. 复旦学报(医学版), 2006, 33(3): 422�423. ［6］ 曹 冬, 黄喜茹, 王 伟
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