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4°C, protect from light
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
5119-48-2
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4038.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1300.0 |
| 规格： | 5 mg | 产品价格： | ￥3900.0 |
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Withaferin A
CAS No. : 5119-48-2
MCE 国际站：Withaferin A
产品活性：Withaferin A 是从睡茄中分离到的甾体内酯，可以抑制 NF-kB 的活性，靶作用于波形蛋白 (vimentin)，具有抗炎，抗肿瘤等功效。Withaferin A 是内皮蛋白 C 受体 (EPCR) 脱落的抑制剂。
研究领域：NF-κB | Apoptosis
作用靶点：NF-κB | Ferroptosis
In Vitro: Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism.
Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM.
Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
In Vivo: Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.
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文献和实验to measure these cellular parameters is important. Recent studies also indicate that many naturally occurring cancer chemopreventive agents, such as watercress constituent phenethyl isothiocyanate and Withania somnifera component withaferin A, alter
, Tanacetum parthenium PPM-18 Sulfasalazine TIRAP Inhibitor Peptide, Cell-Permeable TIRAP Inhibitor Peptide, Control, Cell-Permeable Withaferin A, Withania somnifera LWP1981 我做细胞抑制的时候，用过好几次SN50，觉得SN50对NFKB转录因子的核转移抑制效果不错
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