In Vitro: Adrenocorticotropic hormone (ACTH) is a tropic hormone produced by the anterior pituitary, regulates cortisol and androgen production and is associated with Addison disease, Cushing syndrome and Cushing disease.
In Vivo: ACTH (1-13) alone or in combination with met-enkephalin shows potent cytoprotective effects in the model of ethanol induced gastric lesions in rats, and has immunomodulatory effects.