- ￥191 - 5238
- MedChemExpress(MCE)
- 美国
- HY-17041
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
TMC114 Ethanolate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
635728-49-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥522.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥191.0 |
| 规格： | 5 mg | 产品价格： | ￥400.0 |
| 规格： | 10 mg | 产品价格： | ￥600.0 |
| 规格： | 25 mg | 产品价格： | ￥900.0 |
| 规格： | 50 mg | 产品价格： | ￥1400.0 |
| 规格： | 100 mg | 产品价格： | ￥2150.0 |
| 规格： | 200 mg | 产品价格： | ￥3200.0 |
| 规格： | 500 mg | 产品价格： | ￥5238.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Darunavir Ethanolate
CAS No. : 635728-49-3
MCE 国际站：Darunavir Ethanolate
产品活性：Darunavir Ethanolate (TMC114 Ethanolate) 是一种 HIV 蛋白酶抑制剂，可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的 Ki 值为1 nM。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：HIV | HIV Protease
In Vitro: Darunavir is a broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity. Darunavir forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease. These interactions are proposed to be critical for the potency of this compound against HIV isolates that are resistant to multiple protease inhibitors. In an in vitro study in MT-2 cells, the potency of darunavir is greater than that of saquinavir, amprenavir, nelfinavir, indinavir, lopinavir and ritonavir. Darunavir is primarily metabolized by the hepatic cytochrome P450 (CYP) enzymes, primarily CYP3A. The ‘boosting’ dose of ritonavir acts an an inhibitor of CYP3A, thereby increasing darunavir bioavailability.
In Vivo: Darunavir is effective against wild-type and PI-resistant HIV, and has an oral bioavailability of 37%. It needs to be combined with ritonavir, which increases the bioavailability to 82%.
相关产品：Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Anti-Infection Compound Library | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Antiviral Compound Library | Peptidomimetic Library | Drug Repurposing Compound Library | Covalent Screening Library | Anti-COVID-19 Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Rare Diseases Drug Library | Children’s Drug Library | EMA-Approved Drug Library | Human Metabolite Library | Off-patent Drug Library | Cytokine Inhibitors Library | Chloroquine | Doxorubicin hydrochloride | 5-Fluorouracil | Q-VD-OPh | Valproic acid | Panobinostat | Shikonin | Hydroxyurea | Probenecid | Kaempferol | Plerixafor | Dimethyl fumarate | Pepstatin | Birinapant | Maraviroc | Baicalin | Flavopiridol | Ritonavir | Ivermectin | Fasudil Hydrochloride | Ebselen | Rolipram | Betulinic acid | CK-666 | Oleanolic Acid | Lysozyme from chicken egg white | ONX-0914
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
