RG7834,2072057-17-9

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RG7834

CAS No. : 2072057-17-9

MCE 国际站：RG7834

产品活性：RG7834 (RO 7020322) 是一种高度选择性、可口服的 HBV 抑制剂，在 dHepaRG 细胞中，能够有效抑制 HBV 抗原 HBsAg，HBeAg 和 HBV DNA，IC₅₀ 值分别为 2.8，2.6 和 3.2 nM。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC₅₀s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.
RG7834 has no activity against CYP3A4, CYP2D6, CYP2C9 (IC₅₀s >50 μM) or hERG channel.

In Vivo: RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice.
RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice.

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