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- MedChemExpress(MCE)
- 美国
- HY-15581S
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Demethyldolastatin 10-d<sub>8</sub>; Monomethylauristatin D-d<sub>8</sub>; Monomethyl Dolastatin 10-d<sub>8</sub>
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg
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MMAD-d8
MCE 国际站：MMAD-d8
产品活性：MMAD-d8D是MMAD的氘代形式。
研究领域：Antibody-drug Conjugate/ADC Related | Cytoskeleton | Cell Cycle/DNA Damage
作用靶点：ADC Cytotoxin | Microtubule/Tubulin
In Vitro: MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity.
In Vivo: The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.
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