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货期：电询
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2411007-69-5
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电询
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AcLysValCit-PABC-DMAE-SW-163D
CAS No. : 2411007-69-5
MCE 国际站：AcLysValCit-PABC-DMAE-SW-163D
产品活性：AcLysValCit-PABC-DMAE-SW-163D 是抗体偶联活性分子的一部分 (drug-linker conjugates for ADC), 由天然的双嵌入剂SW-163D 和 linker AcLysValCitPABC-DMAE 偶联构成。
研究领域：Antibody-drug Conjugate/ADC Related
作用靶点：Drug-Linker Conjugates for ADC
In Vitro: SW-163D is a cyclodepsipeptide antibiotic that is isolated from Streptomyces sp. SW-163D also exhibits antitumour activity. PF06888667 is a potent, stable, and efficacious ADC that consists of the bis-intercalator, SW-163D, conjugated via an N-acetyl-lysine-valine-citrulline-p-aminobenzyl alcohol-N,N-dimethylethylenediamine (AcLysValCitPABC-DMAE) linker to an engineered variant of the anti-Her2 mAb, trastuzumab, catalyzed by transglutaminase.
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文献和实验： 158-163 ． 8 ． Molzahn SW,Woods RA.Polyene resistance and the isolation of sterol mutants in Saccharomyces cerevisae.J Gen Microbiol 1972,72 ： 339-348. 9 ． Johnson EM, Wariock DW,Luker J, et al.Emergence of azole drug resistance
Finding Protein and Nucleotide Similarities with FASTA
(sw), the alignment length (alen), the coordinates of the start and end of the alignments in the query (an0, ax0) and library (an1, ax1) sequences, the start and end of the query (pn0, px0) and library (pn1, px1) sequences, the number of gaps
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