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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Nec-1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
4311-88-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥785.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥446.0 |
| 规格： | 10 mg | 产品价格： | ￥714.0 |
| 规格： | 50 mg | 产品价格： | ￥1500.0 |
| 规格： | 100 mg | 产品价格： | ￥1989.0 |
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Necrostatin-1
CAS No. : 4311-88-0
MCE 国际站：Necrostatin-1
产品活性：Necrostatin-1 (Nec-1) 是一种有效的能透过血脑屏障的坏死性凋亡 (necroptosis) 抑制剂，在 Jurkat 细胞中的 EC50 为 490 nM。Necrostatin-1 抑制 RIP1 激酶 (EC50=182 nM) 。Necrostatin-1 (Nec-1) 也是一种 (IDO) 抑制剂。
研究领域：Apoptosis | Autophagy | Metabolic Enzyme/Protease
作用靶点：RIP kinase | Autophagy | Indoleamine 2,3-Dioxygenase (IDO) | Ferroptosis
In Vitro: Necrostatin-1 (Nec-1) efficiently inhibits the TNFα-induced necrotic death of L929 cells, which does not require exogenous caspase inhibitors.
?Necrostatin-1 (Nec-1) prevents radiocontrast media (RCM)-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of contrast-induced AKI (CIAKI).
?Necrostatin-1 (Nec-1) (30 μM) increases the survival of cardiomyocyte progenitor cell (CMPCs) by inhibiting necrotic cell death.
In Vivo: Necrostatin-1 (Nec-1) induces tubular bilation and affects the kinetics of the dilation of peritubular capillaries after RCM application. Upon a single intraperitoneal application of a single dose of Necrostatin-1 (1.65 mg/kg body weight, i.p.) 15 minutes before RCM, the return to baseline levels is prevented within the observation period.
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