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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
RG7388
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1229705-06-9
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1221.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2500.0 |
| 规格： | 50 mg | 产品价格： | ￥3950.0 |
| 规格： | 100 mg | 产品价格： | ￥5950.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Idasanutlin
CAS No. : 1229705-06-9
MCE 国际站：Idasanutlin
产品活性：Idasanutlin (RG7388) 是一种有效，选择性的 MDM2 拮抗剂，能够抑制 p53-MDM2 的结合，IC50 值为 6 nM。
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：MDM-2/p53 | E1/E2/E3 Enzyme
In Vitro: Idasanutlin (RG7388) inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53.
Idasanutlin (RG7388) (300 nM or 1.8 μM) induces apoptosis in SJSA osteosarcoma cells.
In Vivo: Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model.
Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model.
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