CRA-026440,847460-34-8

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CRA-026440

CAS No. : 847460-34-8

MCE 国际站：CRA-026440

产品活性：CRA-026440 是一种有效的广谱 HDAC 抑制剂。作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 的 K_i 分别为 4，14，11，15，7 和 20 nM。CRA-026440 具有抗肿瘤和抗血管生成活性。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Apoptosis

作用靶点：HDAC  |  Apoptosis

In Vitro: CRA-026440 has antiproliferative effect on HUVEC endothelial cells with a GI₅₀ value of 1.41 μM.
CRA-026440 (0.1-10 μM; 18 hours) results in the accumulation of acetylated histone and acetylated tubulin, leading to an inhibition of tumor cell growth and the induction of apoptosis.
CRA-026440 (0.1-10 μM; 5 days) inhibits ex vivo angiogenesis in a dose-dependent manner.

In Vivo: CRA-026440 (100 mg/kg; i.v.; daily; for three consecutive days) results in a statistically significant reduction in tumor growth in mice harboring HCT116 or U937 human tumor xenografts.

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