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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1426944-49-1
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2090.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥880.0 |
| 规格： | 5 mg | 产品价格： | ￥1900.0 |
| 规格： | 10 mg | 产品价格： | ￥3100.0 |
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HBX 19818
CAS No. : 1426944-49-1
MCE 国际站：HBX 19818
产品活性：HBX 19818 是一种泛素蛋白特异性蛋白酶 (USP7) 抑制剂，IC50 值为 28.1 μM。
研究领域：Cell Cycle/DNA Damage
作用靶点：Deubiquitinase
In Vitro: HBX 19818 is an inhibitor of USP7, with an IC50 of 28.1 μM. HBX 19818 shows no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3 or on SENP1, a SUMO protease, with IC50s of > 200 μM. HBX 19818 selectively inhibits USP7 with IC50 of ～6 μM in in human cancer cells. In addition, HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells. HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner, with an IC50 of ～2 μM.
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文献和实验HBx and MHBst products from hepatitis B virus-DNA (HBV-DNA), which become transcriptional transactivators of cellular and viral genes, are known to play causative roles in the development of hepatocellular carcinoma (HCC
Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene
) has been implicated to play a major causative role in the development of HCC in man (2 –4 ). The HBx gene, the smallest viral openreading frame that may be essential for the viral life cycle (5 ,6 ), largely contributes the oncogenecity of HBV. The selective
8.2 Science：重磅！三维打印人类心脏不再是遥远的梦
楚。来自深圳大学生命与海洋科学学院的研究人员发现了植物细胞膜糖基肌醇磷酸神经酰胺鞘脂能应答盐胁迫，导致钙内流，这解码了植物感应盐胁迫信号的分子机理，对进一步揭示植物适应全球环境变化的生理生态效应及分子机制具有重大的理论意义与应用价值。原文检索：Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2 + influx ④ 厦大学者 Nature 子刊揭示对于乙肝病毒复制至关重要的结构HBx 是 HBV 的一个具有多维功能的非结构
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