MA-0204,2095128-17-7

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MA-0204

CAS No. : 2095128-17-7

MCE 国际站：MA-0204

产品活性：MA-0204 是一种有效，高选择性，有口服活性的的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂，对于人，小鼠和大鼠 PPARδ 的 EC₅₀ 分别为 0.4 nM、7.9 nM 和 10 nM。有研究 Duchene 肌营养不良症 (DMD) 的潜力。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶点：PPAR

In Vitro: MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C.

MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice.

MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts.

In Vivo: PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle.

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