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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
C24
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1273323-67-3
- 规格：
10 mM * 1 mL/2 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2132.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥1280.0 |
| 规格： | 5 mg | 产品价格： | ￥2080.0 |
| 规格： | 10 mg | 产品价格： | ￥3320.0 |
| 规格： | 25 mg | 产品价格： | ￥6640.0 |
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YLF-466D
CAS No. : 1273323-67-3
MCE 国际站：YLF-466D
产品活性：YLF-466D 是一种新型 AMPK 激活剂，可抑制血小板聚集。
研究领域：Epigenetics | PI3K/Akt/mTOR
作用靶点：AMPK
In Vitro: The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively.
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文献和实验Isolation of Melanoma Tumor-Initiating Cells from Surgical Tissues
during the course of its progression or relapse (Ailles and Weissman, Curr Opin Biotechnol 18:460–466, 2007; Chan et al., Proc Natl Acad Sci U S A 106:14016–14021, 2009; D’Angelo and Wicha, Prog Mol Biol Transl Sci 95:113–158, 2010; O’Brien, Semin Radiat Oncol 19:71
三句话读懂一篇 CNS，酗酒背后的机制，环境-基因互作诱导肿瘤发生，Cas9 时钟...
Cancer Risk Genes — Association Analysis in More than 113,000 Women，该研究以应用由 34 个推测的易感基因构成的基因面板，对 60,466 例乳腺癌女性患者和 53,461 例对照女性的样本进行了测序，筛选出如 ATM、BRCA1、BRCA2、CHEK2 和 PALB2 等数个预测乳腺癌风险最有用的基因，这些结果能有效用于备孕人士的遗传咨询。乳腺癌作为全球第一大癌症，女性朋友们定要多加防范，做好癌症筛查！ 图片来源：站酷海洛
-102.[3]Dahl C, Guldberg P. DNA methylation analysis techniques [J]. Biogerontology, 2003, 4(4): 233-250.[4]董玉玮,侯进慧,朱必才等. 表观遗传学的相关概念和研究进展[J]. 生命的化学, 2005, 22(1): 1-3.[5]武立鹏, 朱卫国. DNA甲基化的生物学应用及检测方法进展[J]. 中国检验医学杂志, 2004, 27(7): 468-474.[6]Riggs A D, Jones
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