- ￥1100 - 4612
- MedChemExpress(MCE)
- 美国
- HY-101799
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
KDM4B Inhibitor B3
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2003260-55-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2608.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1100.0 |
| 规格： | 5 mg | 产品价格： | ￥3100.0 |
| 规格： | 10 mg | 产品价格： | ￥4612.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
NCGC00244536
CAS No. : 2003260-55-5
MCE 国际站：NCGC00244536
产品活性：NCGC00244536是高效的 KDM4B 抑制剂，IC50 值为10 nM。
研究领域：Epigenetics
作用靶点：Histone Demethylase
In Vitro: NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC50=40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC50s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC50s.
In Vivo: Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.
相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | GSK-J4 | Eicosapentaenoic Acid | IOX1 | JIB-04 | CPI-455 | Iadademstat dihydrochloride | Tranylcypromine hemisulfate | KDM5-C70 | SP2509 | QC6352 | GSK2879552 | GSK-LSD1 dihydrochloride | Pulrodemstat benzenesulfonate | AS8351 | Seclidemstat | KDOAM-25 citrate | Daminozide | ML324 | Corin | GSK467 | KDM5A-IN-1 | PFI-90 | KDM2A/7A-IN-1 | L-2-Hydroxyglutaric acid disodium | Procaine | SKLB325 | Bomedemstat hydrochloride
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验μL 体系 2× MasterMix 25 μL 上游 Primer （ 10 μM 1-5 μL 下游 Primer （ 10 μM ） 1-5 μL 模板 lamid DNA ～ 50 ng genomic DNA ～ 1000 ng cDNA ～ 500 ng 粗提液 ～ 2 μL 灭菌蒸馏水至 50 μL PCR 扩增实例： 一、plasmid DNA 扩增 1．提取的质粒 DNA 扩增 以pUC19 质粒为模板扩增 100，250，500
DNA EXTRACTION FROM MICRODISSECTED PARAFFIN SECTIONS
diiferent blades for each part of the tumor. Overlay with 20 ul mineral oil. Close cap and seal with parafilm. DIGESTION: Incubate overnight for shaking at 120 rpm, 55 C. Day 2: Add 0.3 ul fresh conc Proteinase K (20 mg/ml stock
1. 生信分析文章范例解读 最近在检索文献时发现了 10 月有一篇生信文章，做的是关于三阴性乳腺癌中相关 ceRNA 差异表达谱的综合分析，于 2018 年 10 月 11 日发表在《Cellular physiology and biochemistry》杂志上，IF = 5.5。 由于小编就是做三阴性乳腺癌 non-coding RNA 的相关研究，一直都有关注 ceRNA 的研究，类似这篇文章的工作量投稿分数应为 3-5 分，而此文竟然突破 5 分门槛。 仔细阅读发现，原来这篇文章与常规
技术资料暂无技术资料 索取技术资料
