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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
KDM4B Inhibitor B3
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2003260-55-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2608.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1100.0 |
| 规格： | 5 mg | 产品价格： | ￥3100.0 |
| 规格： | 10 mg | 产品价格： | ￥4612.0 |
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NCGC00244536
CAS No. : 2003260-55-5
MCE 国际站：NCGC00244536
产品活性：NCGC00244536是高效的 KDM4B 抑制剂，IC50 值为10 nM。
研究领域：Epigenetics
作用靶点：Histone Demethylase
In Vitro: NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC50=40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC50s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC50s.
In Vivo: Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis.
相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | GSK-J4 | Eicosapentaenoic Acid | IOX1 | JIB-04 | CPI-455 | Iadademstat dihydrochloride | Tranylcypromine hemisulfate | KDM5-C70 | SP2509 | QC6352 | GSK2879552 | GSK-LSD1 dihydrochloride | Pulrodemstat benzenesulfonate | AS8351 | Seclidemstat | KDOAM-25 citrate | Daminozide | ML324 | Corin | GSK467 | KDM5A-IN-1 | PFI-90 | KDM2A/7A-IN-1 | L-2-Hydroxyglutaric acid disodium | Procaine | SKLB325 | Bomedemstat hydrochloride
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