- ￥5488
- MedChemExpress(MCE)
- 美国
- HY-16014
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
406228-55-5
- 规格：
10 mM * 1 mL///100 mg
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
A-385358
CAS No. : 406228-55-5
MCE 国际站：A-385358
产品活性：A-385358 是 Bcl-XL 的一个选择性抑制剂，对于 Bcl-XL 和 Bcl-2 的 Ki 值分别为 0.80 和 67 nM。
研究领域：Apoptosis
作用靶点：Bcl-2 Family
In Vitro: A-385358 is a selective inhibitor of Bcl-XL with Kis of 0.80 and 67 nM for Bcl-XL and Bcl-2, respectively, in fluorescence polarization assays. Treatment of IL-3-deprived FL5.12/Bcl-XL cells for 24 hours with A-385358 results in cell killing with an EC50 of 0.47±0.05 μM (n=68). This effect is accompanied by an increase in caspase-3 activity. Consistent with the greater affinity for the Bcl-XL versus Bcl-2 hydrophobic grooves, the EC50 of A-385358 for IL-3-depleted FL5.12/Bcl-2 cells (1.9±0.1 μM; n=55) is 4-fold higher relative to the cytokine-deprived FL5.12/Bcl-XL cells. In addition, A-385358 is more effective at stimulating cytochrome c release from mitochondria isolated from FL5.12/Bcl-XL versus Bcl-2 cells.
In Vivo: The combination of A-385358 given at 100 mg/kg/d plus the lower dose of paclitaxel produces a significant reduction in tumor growth (%T/C) compare with paclitaxel monotherapy. This combination also yields a >100% increase in time for tumors to reach 900 mm3 (%ILS) compare with vehicle control. Maximal efficacy is observed during the dosing period for A-385358, with slow but steady increase in the tumor growth after termination of treatment. The combination of A-385358 at 75 mg/kg/d plus paclitaxel at 30 mg/kg/d is also well tolerated and inhibits tumor growth rate by nearly 80%. Significant effects on tumor growth relative to paclitaxel monotherapy are observed with doses as low as 50 mg/kg/d.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Peptidomimetic Library | Anti-Blood Cancer Compound Library | Mitochondria-Targeted Compound Library | Targeted Diversity Library | Highly Selective Inhibitors Library | Venetoclax | Navitoclax | Polyinosinic-polycytidylic acid | S63845 | ABT-737 | A-1331852 | AZD-5991 | BT2 | Chlorin e6 | A-1155463 | MIK665 | Estradiol benzoate | BAI1 | Benzbromarone | Obatoclax Mesylate | Digitoxin | Chelerythrine chloride | BI-3802 | AZD4320 | Dehydrocorydaline | WEHI-539 hydrochloride | Tapotoclax | Amantadine | A-1210477 | Gambogic Acid | BTSA1 | Bax inhibitor peptide V5 | UMI-77 | Cardamonin | TCPOBOP
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
