TPOP146,2018300-62-2

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TPOP146

CAS No. : 2018300-62-2

MCE 国际站：TPOP146

产品活性：TPOP146是选择性的CBP/P300苯并西泮溴结构域抑制剂；对CBP和BRD4的K_d值分别为134 nM和5.02 μM。

研究领域：Epigenetics

作用靶点：Epigenetic Reader Domain  |  Histone Acetyltransferase

In Vitro: Exposure to 1 μM TPOP146 results in a significant decrease of recovery half-life that is comparable to the construct that contained the bromodomain inactivating mutation N1168F, demonstrating that TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments.

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