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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1698055-86-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1398.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥613.0 |
| 规格： | 5 mg | 产品价格： | ￥1475.0 |
| 规格： | 10 mg | 产品价格： | ￥2113.0 |
| 规格： | 25 mg | 产品价格： | ￥3513.0 |
| 规格： | 50 mg | 产品价格： | ￥4925.0 |
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ARS-1630
CAS No. : 1698055-86-5
MCE 国际站：ARS-1630
产品活性：ARS-1630 是 ARS-1620 的低活性对映体，是突变型 K-Ras G12C 的新型抑制剂，来自专利 WO 2015054572 A1。
研究领域：GPCR/G Protein
作用靶点：Ras
In Vitro: KRASG12C is recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP is restricted only to the GDP-bound state. This strategy proves feasible for inhibiting mutant KRAS in vitro.
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