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JAK-IN-5
CAS No. : 2096999-92-5
MCE 国际站：JAK-IN-5
产品活性：JAK-IN-5 是 JAK 的抑制剂，来自专利US20170121327A1，化合物实例 283。
研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：JAK
In Vivo: JAK-IN-5 (compound 1) (oral aspirate, 0.5 mg/mL, 50 μL ) inhibits STAT6 phosphorylation by 60% in IL-13-induced in lung tissue in a mouse model of pSTAT6 induction.
JAK-IN-5 (compound 1) (oral aspirate, 0.1-1.0 mg/mL, 50 μL) inhibits 88% of BALF eosinophils in male C57 mice model of Alternaria alternata-induced eosinophilic inflammation of the lung.
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文献和实验cells, including basophils and dendritic cells, might contribute to the polarization of TH2 cells. IL-33 exerts dual functions on TH2 cells: it acts not only as an activator and chemoattractant, but also as a regulator, by reducing production of IL-5
(1.30-5.60)122±0.98125±0.96(120-146)4.87±0.845.06±0.93(3.80-7.95)92.3±1.0496.5±1.19(90.0-115)22.0±4.0020.9±3.80(12.8-30.0)5.33±1.155.30±1.10(3.00-7.63)9.60±0.6310.7±0.58(8.30-12.0)2.35±0.252.46±0.27(1.80-3.00)兔0.32±0.040.30±0.04(0.00-0.74)26.7±12.924.5±
.0 ALT U/L 31.38±9.92 276 12.44-63.60
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