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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1394371-71-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥409.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥3000.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
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MK8722
CAS No. : 1394371-71-1
MCE 国际站：MK8722
产品活性：MK8722 是一种有效的全身 pan-AMPK 激活剂。
研究领域：Epigenetics | PI3K/Akt/mTOR
作用靶点：AMPK
In Vitro: MK8722 (MK-8722) is a potent, direct, allosteric activator of all 12 mammalian AMPK complexes. MK8722 activates pAMPK complexes with increased potency and magnitude versus AMP, with EC50 values of ~1 to 60 nM and increased activation by factors of ~4 to 24. Although MK8722 exhibits higher affinity for β1-containing (~1 to 6 nM) versus β2-containing (~15 to 63 nM) pAMPK complexes, it is the most potent activator of β2 complexes reported to date. pAMPK activation by maximal AMP plus MK8722 is synergistic, demonstrating that the agents act at distinct sites.
In Vivo: Chronic antihyperglycemic efficacy of MK8722 (MK-8722) is evaluated in db/db mice, a leptin receptor-deficient T2DM model. Once-daily administration of MK8722 results in dose-dependent lowering of ambient blood glucose. On treatment day 12, glucose reductions after MK8722 treatment (30 mpk/day) are comparable to those observed with the PPARγ agonist BRL49653 (3 mpk/day). Unlike BRL49653, the glucose-lowering action of MK8722 manifests without significant effects on body weight, which is a consistent finding. Dose-dependent increases in tissue pACC are maintained throughout the dosing period. Chronic efficacy, without tachyphylaxis, is also observed in additional dysmetabolic and diabetic rodent models. In all cases, efficacy is associated with trough MK8722 plasma levels comparable to the concentrations required to acutely stimulate skeletal muscle glucose uptake. Chronic MK8722 dosing in mice also increases muscle Glut4 protein levels, possibly contributing to efficacy.
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文献和实验素K2 (MK-4);及两种胡萝卜素：番茄红素及β-胡萝卜素均购自西格玛公司(Sigma Aldrich)，并且未经处理直接使用。将所有样品以约0.1 mg/mL的溶解到甲基第三丁基醚(MTBE)中，并转移到进样瓶中，准备进行分析。 UPC2条件： 系统： 配备PDA检测器的ACQUITY UPC2 流速： 1 mL/min 流动相A：CO2 流动相B：乙腈 色谱柱： ACQUITY UPLC HSS C18 3.0 x
about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet, 29(4): 365-71. 19• Brown MP, Grundy WN, Lin D, Cristianini N, Sugnet CW, Furey TS, Ares M, Jr. and Haussler D. 2000. Knowledge-based analysis of microarray gene expression data
(5):1042-6, 1048-55. [2] Sartor M, Schwanekamp J, Halbleib D, et al. Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques, 2004,36(5):790-796. [3] McQuain MK, Seale K, Peek J, et al. Chaotic mixer improves
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