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- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 英文名：
GTPL7512
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
916489-36-6
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 1 mg | 产品价格： | ￥394.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥1900.0 |
| 规格： | 50 mg | 产品价格： | ￥2900.0 |
| 规格： | 100 mg | 产品价格： | ￥4300.0 |
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MS417
CAS No. : 916489-36-6
MCE 国际站：MS417
产品活性：MS417 是一种选择性的 BET 特异性蛋白 BRD4 的抑制剂，能够与 BRD4-BD1 和 BRD4-BD2 结合，IC50 值分别为 30，46 nM，Kd 值分别为 36.1，25.4 nM; MS417 对 CBP BRD 的选择性较低，IC50 值为 32.7 μM。
研究领域：Epigenetics | Anti-infection
作用靶点：Epigenetic Reader Domain | HIV
In Vitro: MS417 is a BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with less selectivity at CBP BrD (IC50, 32.7 μM). MS417 effectively blocks BRD4 binding to NF-κB, almost completely suppresses TNFα-induced NF-κB transcription activation in human embryonic kidney 293T cells at 1 μM and also reduces NF-κB p65 acetylation in the HIV-infected RTECs. MS417 (1 μM) modulation of gene transcription in HIV-infected human primary renal tubular epithelial cells. In addition, MS417 suppresses NF-κB-targeted cytokines and chemokines.
In Vivo: MS417 (0.08 mg/kg) markedly improves renal function, reduces proteinuria and decreases glomerulosclerosis, tubular injury, and infiltration of inflammatory cells in the kidney of Tg26 mice.
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文献和实验acrylamide/0.8 g Bis to 100 ml with Super Q water and filtered through 0.2 µm filter.B. 1.5 M Tris, pH 8.8= 36.3 g Tris in 100 ml water. pH to 8.8 and adjust to 200ml.C. 0.5 M Tris, pH 6.8=6 g Tris in 40 ml water. pH to 6.8 and then adjust to 100 ml.D. 10
acrylamide/0.8 g Bis to 100 ml with Super Q water and filtered through 0.2 µm filter.B. 1.5 M Tris, pH 8.8= 36.3 g Tris in 100 ml water. pH to 8.8 and adjust to 200ml.C. 0.5 M Tris, pH 6.8=6 g Tris in 40 ml water. pH to 6.8 and then adjust to 100 ml.D. 10
. (2004) Identification of specific plant nucleolar phosphoproteins in a functional proteomic analysis. P ro teo m ics 4, 407^417. 12 . Matfa, I., Gonzalez-Camacho, F., Marco, R., Kiss, J.Z., Gasset, G., and Medina,F.J. (2005) Nucleolar structure
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