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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
460746-46-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥2100.0 |
| 规格： | 25 mg | 产品价格： | ￥4500.0 |
| 规格： | 50 mg | 产品价格： | ￥8400.0 |
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ABT-239
CAS No. : 460746-46-7
MCE 国际站：ABT-239
产品活性：ABT-239 是一种新颖的，高效的，非咪唑类的 H3R 拮抗剂，也是 TRPV1 的拮抗剂。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Membrane Transporter/Ion Channel
作用靶点：Histamine Receptor | TRP Channel
In Vitro: Perfusion of the TMN with ABT-239 (10 μM) increases histamine release from the TMN, NBM, and cortex, but not from the striatum or NAcc. TMN perfusion with ABT-239 activates c-Fos selectively in the NBM and cortex.
In Vivo: ABT-239 (3 mg/kg, i.p.) significantly delays onset of seizure, reduces behavioral seizures elicited by KA, and reduces in the incidence of head bobbing and forelimb clonus in mice. ABT-239 (1 mg/kg, i.p.) in conbination with sub-therapeutic dose of SVP (150 mg/kg, i.p.), significantly decreases the number of immobility, head bobbing and forelimb clonus, where as a higher dose combination of ABT-239 (3 mg/kg, i.p.) causes enhanced reduction in all the stages. ABT-239 (3 mg/kg, i.p.) and TDZD-8 (10 mg/kg, i.p.) have more powerful reduction in the number of pyknotic neurons in mice hippocampi. The high dose combination of ABT-239 and TDZD-8 produces the most pronounced increase in Bcl-2 expression as well as decrease in the level of Bax. ABT-239 (3 mg/kg, i.p.) administration transforms a short-term learning event into a long-term remembered experience in WT but not in histamine-depleted mice. Concomitant administration of either ABT-239 (1 and 3 mg/kg, i.p.) and nicotine (0.035 mg/kg, i.p.), or ABT-239 (0.1 mg/kg, i.p.) and nicotine (0.0175 mg/kg, i.p.) further increases nicotine-induced improvement in both memory acquisition and consolidation.
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文献和实验核的反应。具有核裂变的核燃料有铀 -235 、铀 -233 、钚 -239 ，目前正在运转的核电厂所使用的是铀 -235 。用慢中子轰击铀 -235 时，就起下列裂变反应： 裂变产物非常复杂，已发现的裂变产物有 35 种元素（从 30 Zn 到 64 Gd ），放射性核有 200 种以上。 核裂变所释放出的大量能量与质量亏损有关，可用爱因斯坦（ A ． Einstein ）公式进行计算 △ E= △ mc
产品介绍 真空干燥箱，DZF-6000系列专为热敏性、易分解和易氧化物质而设计，能够箱内部充入惰性气体，特别是一些成分复杂的物品也能进行快速干燥。ABT工程检测仪器网 新一代真空干燥箱，集公司多年咋箱体加热方面的成功经验，通过不断潜心研究，突破传统技术创造性解决了在热传导过程中的“瓶颈”——寻找到完美的热传导方式。 产品特点： 1、长方体工作室，使有效容积达到最大，微电脑温度控制器，控温精确可靠。 ABT工程检测仪器网
Identifying and Characterizing HIV Protease Inhibitors
have been designed and synthesized since, in fact, four protease inhibitors—saquinavir (Ro-31,8959), ritonavir (ABT-538), indinavir (L-735,524), and Nelfinavir (AG1343)—are effective in clinical trials to treat HIV disease (4 –6 ) and recently were approved
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