BI-671800,1093108-50-9

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BI-671800

CAS No. : 1093108-50-9

MCE 国际站：BI-671800

产品活性：BI-671800 是高特异性的、有效的前列腺素 D2 受体 (DP2/CRTH2) 的拮抗剂，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC₅₀ 值分别为 4.5 nM 和 3.7 nM。有研究哮喘的潜力。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: BI-671800 (compound A) exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.

In Vivo: BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice.
BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals.

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