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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1422269-30-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥831.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥329.0 |
| 规格： | 5 mg | 产品价格： | ￥663.0 |
| 规格： | 10 mg | 产品价格： | ￥1041.0 |
| 规格： | 25 mg | 产品价格： | ￥2113.0 |
| 规格： | 50 mg | 产品价格： | ￥3388.0 |
| 规格： | 100 mg | 产品价格： | ￥5413.0 |
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ML-18
CAS No. : 1422269-30-4
MCE 国际站：ML-18
产品活性：ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3 (BRS-3) 拮抗剂。
研究领域：GPCR/G Protein
作用靶点：Bombesin Receptor
In Vitro: ML-18 inhibits specific 125I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells.
相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Anti-Cancer Compound Library | Covalent Screening Library | Anti-Lung Cancer Compound Library | Targeted Diversity Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bombesin | MK-5046 | PD176252 | RC-3095 TFA | Kuwanon G | PD 168368 | Litorin | BA 1 TFA | Kuwanon H | (D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) | BIM 23042 | BIM-26226 | BRS-3 receptor agonist-2 | DSO-5a | GB-6 | GRP (14-27) (human, porcine, canine) | Ranatensin | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | [D-Phe12,Leu14]-Bombesin | [Tyr4]-Bombesin
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文献和实验with 4 x 2.0ml (1 vol.)0.3m KCl Buffer C " " " 0.6M " " . " " " 1.0M " " . " " " 1.5M " " . " " " 2.0M " " . Sample loaded at 9:30 - first pars by 10:30,second by 11:30. Washes done by @1:30. Elutions done by @3:30-4:00 Rinsed column
band and serum with suction. (See attached figure, in preparation)Wash in PBS (or media A) to remove Histopaque (spin 1800 rpm/5 min at 4o C)Remove PBS (or media A) , add 18 ml cold H2 O to lyse RBC, and add 2 ml 10x PBS.Spin 1400 rpm/5min at 4o C.Wash
- - - - 1× HEPES - - - - 15mM Activin A 100ng/ml 100ng/ml 100ng/ml 100ng/ml - C687 FGF-4 - - - 500ng/ml - CR08 Wnt3a - - - 500ng/ml - C06D/C18K Noggin - - - - 100ng/ml CB89
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