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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2018282-44-3
- 规格：
5 mg/10 mg/25 mg
| 规格： | 5 mg | 产品价格： | ￥1900.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥3200.0 |
| 规格： | 25 mg | 产品价格： | ￥5300.0 |
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BMT-145027
CAS No. : 2018282-44-3
MCE 国际站：BMT-145027
产品活性：BMT-145027是 mGluR5 的正变构调节物且没有固有的激动剂活性，EC50值为47 nM。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：mGluR
In Vitro: BMT-145027 is a compound with high MsLM stability (85% remaining), acceptable potency (EC50=47 nM), and a modest decrease in planarity (Fsp3 = 0.17). Importantly, BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM.
In Vivo: Drug-treated and control mice are shown two identical objects. After a 24-h natural forgetting period, the mice are reintroduced to a familiar object while simultaneously presented with a novel object. Since mice spend more time exploring unfamiliar objects, improved memory is measured as time spent exploring the novel object. BMT-145027 leads to a significant increase in time spent with the novel object when dosed at 30 mg/kg, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals indicates a total plasma concentration of 2800 nM at 30 mg/kg.
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