Dehydronitrosonisoldipine

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Dehydronitrosonisoldipine

CAS No. : 87375-91-5

MCE 国际站：Dehydronitrosonisoldipine

产品活性：Dehydronitrosonisoldipine，是尼索地平 Nisoldipine (HY-17402) 的衍生物，是一种可逆且具有细胞渗透性的 SARM1 抑制剂。Dehydronitrosonisoldipine 主要通过阻断 SARM1 的激活而不是阻断其酶活性来发挥作用。Dehydronitrosonisoldipine 通过共价修饰半胱氨酸抑制 SARM1 和轴突退化 (AxD)，也抑制 Vincristine 激活的神经元 cADPR 的产生。Dehydronitrosonisoldipine 可用于研究神经退行性疾病。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: Dehydronitrosonisoldipine exhibits an IC₅₀ of 4 μM in the SARM1-dN-expression cells, and decreases the cellular cADPR in cells expressing SARM1, but not in expressing SAM-TIR cells.

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