diABZI STING agonist-1 (tautom

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diABZI STING agonist-1 (Tautomerism)

CAS No. : 2138498-18-5

MCE 国际站：diABZI STING agonist-1 (Tautomerism)

产品活性：diABZI STING agonist-1 Tautomerism (compound 3) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC₅₀ 值分别为 130 nM 和 186 nM。。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested.

In Vivo: diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo.
diABZI STING agonist-1 (Tautomerism) (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC₅₀) for mouse STING (200 ng/ml).
diABZI STING agonist-1 (Tautomerism) (intravenous injection; 1.5 mg/kg; 43 days) results in significant tumour growth inhibition and significantly improves survival (P < 0.001) with 8 out of 10 mice remaining tumor free at the end of the study on day 43.

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