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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2162962-69-6
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1250.0 |
| 规格： | 10 mg | 产品价格： | ￥1990.0 |
| 规格： | 25 mg | 产品价格： | ￥3284.0 |
| 规格： | 50 mg | 产品价格： | ￥4597.0 |
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CU-CPT9b
CAS No. : 2162962-69-6
MCE 国际站：CU-CPT9b
产品活性：CU-CPT9b 是 TLR8 的特异性拮抗剂，其 IC50 值为 0.7 nM。CU-CPT9b 高亲和性结合 TLR8， Kd 值为 21 nM。
作用靶点：Toll-like Receptor (TLR)
In Vitro: CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m.
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