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- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
3M-852A
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
532959-63-0
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1948.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥950.0 |
| 规格: | 5 mg | 产品价格: | ¥2450.0 |
| 规格: | 10 mg | 产品价格: | ¥3900.0 |
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PF-4878691
CAS No. : 532959-63-0
MCE 国际站:PF-4878691
产品活性:PF-4878691 (3M-852A) 是一种有口服活性的 TLR7 激动剂。PF-4878691 具有固有免疫应答活性,对 HCV 具有抗病毒作用,可用于肿瘤的研究。
研究领域:Immunology/Inflammation | Apoptosis | Anti-infection
作用靶点:Toll-like Receptor (TLR) | Apoptosis | TNF Receptor | HCV | Interleukin Related
In Vitro: PF-4878691 (10 μM, 4 h) induces a complex transcription network responsible for activating plasmacytoid dendritic cells for innate antiviral immune responses with optimized responses towards RNA viruses, increases co-stimulatory capacity, and increases survival in plasmacytoid dendritic cells.
In Vivo: PF-4878691 (10-150 mg, Oral gavage, single dose) induces pharmacology in BALB/c mice and C57bl/6 J mice.
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proteins from a DEAE anion‐exchange column showing molybdenum (‐x‐) and protein (⋅⋅ o ⋅⋅) concentrations. Box shows fractions pooled for PF1972 purification (adapted from Cvetkovic et al., ). View Image
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