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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1391737-01-1
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥3300.0 |
| 规格： | 50 mg | 产品价格： | ￥5300.0 |
| 规格： | 100 mg | 产品价格： | ￥8500.0 |
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VU0463271
CAS No. : 1391737-01-1
MCE 国际站：VU0463271
产品活性：VU0463271 是选择性的神经特异性氯钾协同转运蛋白 2 (KCC2) 的有效抑制剂，其 IC50 值为 61 nM。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Potassium Channel
In Vitro: VU0463271 is a potent antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels and transporters. It is also found rapidly cleared in vitro.
VU0463271 is applied to the transected CNS preparation and resulted in a significant increase in firing rates of the Drosophila CNS with 1 μM VU0463271 resulting in a peak firing rate that was a 2.7- and 2.5-fold increase over baseline firing rate for OR and rdl strains, respectively.
VU0463271 (10-100 nM) results in approximately 20% reduction of CNS firing frequency within asmall percentage of preparations.
In Vivo: VU0463271 is found to be a moderate-to-high clearance compound in rat (CL=57 mL/min/kg) following intravenous administration (1 mg/kg); the low volume of distribution at steady state (Vss 0.4 L/kg), coupled with moderate-to-high clearance produce a relatively short t1/2 (9 min) in vivo.
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文献和实验受体BCR。 天然Ig的基本结构是一Y型的四肽链。 免疫球蛋白的基本结构示意图 典型的Is分子基本结构呈“Y”字型，由两条相同的重链(H)和两条相同的轻链(1。)借二硫键连接而成。重链和轻链近氨基端的l／4或l／2氨基酸序列的变化很大，为可变区；其他部分氨基酸序列则相对恒定，为恒定区；位于CHI与CH2之间、富含脯氦酸的区域为铰链区。 Vu和VL分别代表重链和轻链的可变区，Cu和CI。分别代表重链和轻链的恒定区。
PRALINE: A Versatile Multiple Sequence Alignment Toolkit
are enabled as well. PRALINE is accessible via the online server http://www.ibi.vu.nl/programs/PRALINEwww/ . The server facilitates extensive visualization possibilities aiding the interpretation of alignments generated, which can be written
Western Blot Analysis for Tissue
相关专题 Author:Dang Vu Hoang Source:Laboratory of Vet.Biochemistry and Molecular Biology, Chungbuk National University, Republic of Korea Abstract: This protocol was used for tissues in detail to detect signals
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