ML335,825658-06-8

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ML335

CAS No. : 825658-06-8

MCE 国际站：ML335

产品活性：ML335 是 TREK-1 和 TREK-2 的选择性激活剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Xenopus oocyte two-electrode voltage-clamp measurements show that ML335 and ML402 activate K_2P2.1 and K_2P10.1 but not K_2P4.1 (14.3±2.7 μM, K_2P2.1-ML335; 13.7±7.0 μM, K_2P2.1-ML402; 5.2±0.5 μM, K_2P10.1-ML335; and 5.9±1.6 μM, K_2P10.1-ML402). Swapping the Lys271 equivalent between K_2P2.1 and K_2P4.1 results in a clear phenotype reversal for ML335 and M402 activation. ML335 and ML402 activate K_2P2.1 in HEK293 cells similar to their effects in Xenopus oocytes (5.2±0.8 μM and 5.9±1.6 μM for ML335 and ML402, respectively (n≥3)).

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuroprotective Compound Library  |  Mechanoreceptors Compound Library  |  Potassium Channel Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Activators Library  |  Ion Channel Compound Library  |  Nigericin sodium salt  |  Yoda 1  |  BAPTA-AM  |  Minocycline hydrochloride  |  Branaplam  |  Rosuvastatin Calcium  |  SCH-23390 hydrochloride  |  Glibenclamide  |  Quinidine (15% dihydroquinidine)  |  Tetrandrine  |  Carbamazepine  |  20(S)-Ginsenoside Rg3  |  DCPIB  |  E-4031  |  Amiodarone hydrochloride  |  Minoxidil  |  TRAM-34  |  Tannic acid  |  (±)-Naringenin  |  Quinine  |  Terfenadine  |  SKF-96365 hydrochloride  |  Mefloquine hydrochloride  |  4-Aminopyridine  |  GW9508  |  PAP-1  |  Astemizole  |  Flufenamic acid  |  Guanosine 5'-diphosphate disodium salt  |  Tolbutamide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds