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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1253186-56-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥743.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥400.0 |
| 规格： | 5 mg | 产品价格： | ￥850.0 |
| 规格： | 10 mg | 产品价格： | ￥1360.0 |
| 规格： | 25 mg | 产品价格： | ￥2720.0 |
| 规格： | 50 mg | 产品价格： | ￥4080.0 |
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GSK-7975A
CAS No. : 1253186-56-9
MCE 国际站：GSK-7975A
产品活性：GSK-7975A是高效有口服活性的 CRAC 通道抑制剂。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vitro: GSK-7975A reduces FcεRI-dependent Ca2+ influx and 3 μM GSK-7975A reduces the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα) by up to 50%. GSK-7975A inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety species. GSK-7975A completely inhibits calcium influx through CRAC channels. This leads to inhibition of the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations. Mast cells from guinea-pig and mouse preparations are not inhibited by GSK-7975A; however cytokine release is fully blocked from T-cells in a mouse preparation. GSK-7975A inhibits toxin-induced activation of ORAI1 and/or activation of Ca2+ currents after Ca2+ release, in a concentration-dependent manner, in mouse and human pancreatic acinar cells (inhibition >90% of the levels observed in control cells). GSK-7975A also prevents activation of the necrotic cell death pathway in mouse and human pancreatic acinar cells.
In Vivo: GSK-7975A inhibits local and systemic features of acute pancreatitis in TLCS-AP, CER-AP, FAEE-AP, in dose- and time-dependent manners.? GSK-7975A significantly reduces increases in serum amylase, IL6, and pancreatic MPO levels; lung MPO is reduced significantly by low dose only. GSK-7975A markedly reduces pancreatic histopathology in TLCS-AP, CER-AP, and FAEE-AP.
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文献和实验DNA extraction from Mutation Detection Enhancement (MDE) Gel Stained with Silver Nitrate
'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â phosphorylation. The PCR conditions consisted of 1 cycle at 95˚C for 5 min; 40 cycles at 95˚C for30 sec, 55˚C for 45 sec, and 72˚C for 75 sec; at a final
【翻译】Development trends for monoclonal antibody cancer therapeutics
two murine, Y-90 ibritumomab tiuxetan (Zevalin; Biogen Idec) and I-131 tositumomab (Bexxar; Corixa/GSK), and one chimeric, I-131 ch-TNT (Shanghai Medipharm Biotech) — have been approved for non-Hodgkin's lymphoma or lung cancer, but only 14% of anticancer
DNA extraction from Mutation Detection Enhancement (MDE) Gel
DNA polymerase (Cinagen, Tehran, IRAN). The primers used were 3-A (5'-TAGTCACTGGCAACAGTCTT-3') and 3-B (5'-AAAATCCCTGTTCCCACTCATAC¨C3'); these amplified a 146-bp fragment of exon 3 of the CTNNB1 gene, encompassing the sequence for GSK-3¦Â
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