GNE-6468,1677668-27-7

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GNE-6468

CAS No. : 1677668-27-7

MCE 国际站：GNE-6468

产品活性：GNE-6468 是一个有效且有选择性的 RORγ (RORc) 反向激动剂，EC₅₀ 值为 2 nM。GNE-6468 抑制 PBMC 中 IL-17 的 EC₅₀ 值为 30 nM。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：ROR

In Vivo: GNE-6468 (compound 28) displays high predicted clearance values in human and rodent hepatocytes (CL_hep = 17 and 42 mL/min/kg, respectively) .

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