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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
GS9132
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货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
870142-71-5
- 规格：
询盘
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ACH-806
CAS No. : 870142-71-5
MCE 国际站：ACH-806
产品活性：ACH-806 是一种 NS4A 拮抗剂，可抑制丙型肝炎病毒 (HCV) 的复制，其 EC50 值为 14 nM。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：HCV Protease | HCV
In Vitro: ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. ACH-806 treatment results in significant reductions of both NS3 and NS4A in the transfected cells. This finding is reminiscent of ACH-806-treated replicon cells in which the amounts of NS3 and NS4A are also both decreased. The total amount of NS3 in the ACH-806-treated sample is reduced by ~6-fold (100/16) and causes a reduction of NS4A-bound NS3 ~29-fold (261/9). The levels of labeled NS3 and NS4A immunoprecipitated by anti-NS3 antibody are apparently reduced after the treatment of ACH-806. ACH-806 also induces significant decreases of NS3 and NS4A and promotes p14 formation in the parental replicon cells but not in the ACH-806-resistant replicon cells.
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文献和实验0.1M ATP (pH 7.2): 5.71% (w/w) ATP, 84.86% (w/w) H2 O, 9.43% (w/w) 2M Tris base. adjust to pH7.5 by 2M NaOH (~70-80µl); prepare about 700µl, dilute 2000 times (it is the final dilution in the spectrofotometric cell), check the optical density: C
"cosuppression", since the expression of both the introduced gene and the homologous endogenous gene was suppressed (1-5).First thought to be a quirk of petunias, cosuppression has since been found to occur in many species of plants. It has also been observed
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