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- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1358099-18-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1611.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥685.0 |
| 规格： | 5 mg | 产品价格： | ￥1600.0 |
| 规格： | 10 mg | 产品价格： | ￥2600.0 |
| 规格： | 25 mg | 产品价格： | ￥4538.0 |
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C25-140
CAS No. : 1358099-18-9
MCE 国际站：C25-140
产品活性：C25-140 是一种首创的，具有口服活性和一定选择性的 TRAF6-Ubc13 相互作用的抑制剂，直接与 TRAF6 结合，阻断 TRAF6 和 Ubc13 的相互作用，从而降低 TRAF6 活性，降低 NF-κB 的活性，并对抗自身免疫。
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：TNF Receptor | E1/E2/E3 Enzyme
In Vitro: C25-140 dose-dependently impedes TRAF6-Ubc13 interaction.
?C25-140 (10-30 μM; 2 hours) effectively reduces TRAF6-mediated ubiquitin chain formation.
?C25-140 affects TNFα-induced phosphorylation of IκBα as well as NF-κB-induced target gene expression.
?C25-140 efficiently inhibits IL-1β- and TNFα-mediated receptor signaling in the context of cytokine activation.
In Vivo: C25-140 (~1.5 mg/kg; topically to the shaved back and the right ear; twice daily for 6 days) ameliorates symptoms of autoimmune psoriasis in R 837-induced psoriasis mouse model.
?C25-140 (6-14 mg/kg; given i.p.; twice daily for 14 days) shows a dose-dependent improvement of RA disease outcome in Collagen-induced arthritis (CIA) model.
?C25-140 (10 mg/kg; i.v.) treatment shows that the Cmax, AUC, t1/2 and Vd are 9.7 μg/mL, 274083 ng min/mL, 80.62 min, and 4.13 L/kg, respectively.
.?C25-140 (10 mg/kg; p.o.) treatment shows that the Cmax, AUC, t1/2 and Vd are 3.4 μg/mL, 124034 ng min/mL, 127.33 min and 13.3 L/kg, respectively.
?C25-140 (10 mg/kg; i.p.) treatment shows that the Cmax, AUC, t1/2 and Vd are 4.2μg/mL, 100000 ng min/mL, 184 min, 25.6 L/kg, respectively.
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文献和实验use 50 ml cells OD600nm = 0.7 - 1.0 per timepoint / sample add 1.35 ml 37 % Formaldehyde (endconcentration = 1 %), incubate 15 min at 25 °C add 2.5 ml 2.5 M Glycine , incubate 5 min at 25 °C spin down, wash
Replication timing by density transfer
C]- acetate or glucose 0.01% (w/v) [15 N]- ammonium sulfate Amino acids/supplements (as required, added to the same concentration as in normal synthetic medium) --dissolved in "-N" medium and filtered
band and serum with suction. (See attached figure, in preparation)Wash in PBS (or media A) to remove Histopaque (spin 1800 rpm/5 min at 4o C)Remove PBS (or media A) , add 18 ml cold H2 O to lyse RBC, and add 2 ml 10x PBS.Spin 1400 rpm/5min at 4o C.Wash
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