- ￥1200 - 5500
- MedChemExpress(MCE)
- 美国
- HY-114334
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
CB839 derivative
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1633.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1900.0 |
| 规格： | 50 mg | 产品价格： | ￥5500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Glutaminase-IN-1
CAS No. : 2247127-79-1
MCE 国际站：Glutaminase-IN-1
产品活性：Glutaminase-IN-1 (CB839 derivative) 是CB839 的一个衍生物，是1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，其IC50 值为1 nM。Glutaminase-IN-1 (CB839 derivative) 具有提高细胞摄取和抗肿瘤的活性。
研究领域：Metabolic Enzyme/Protease
作用靶点：Glutaminase
In Vitro: Glutaminase-IN-1 (CPD20), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 shows improved cellular uptake and antitumor activity. The IC50 values of Glutaminase-IN-1 are 17 nM, 6.78 μM, 19 nM and 9 nM in A549, H2, Caki-1 and HCT116 cell lines, respectively. Glutaminase-IN-1 has better KGA inhibitory activity than the corresponding BPTES and CB839.
In Vivo: Glutaminase-IN-1(10 mg/kg, s.c.) reduced the size and weight of the HCT116 tumor, and statistical analysis showed that the 40% reduction in tumor weight by CPD20 is statistically significant. Glutaminase-IN-1 could statistically significantly prolong the survival of H22-bearing mice.
相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Metabolism Compound Library | Mitochondria-Targeted Compound Library | Cuproptosis Compound Library | Heterocyclic Compound Library | Telaglenastat | BPTES | 6-Diazo-5-oxo-L-nor-Leucine | JHU-083 | Glutaminase C-IN-1 | ZED-1227 | GK921 | IPN60090 | Cystamine | Glutaminase-IN-3 | KCC009 | TG-2-IN-1 | L-Albizziin | UPGL00004 | 2-Amino-2-(p-tolyl)acetic acid | GLS-1-IN-1 | Zampilimab | A-446 | AA10 | Barbinervic acid | BJJF078 | Cystamine-d8 (dihydrochloride） | GLS1 Inhibitor-3 | GLS1 Inhibitor-4 | GLS1 Inhibitor-6 | GLS1 Inhibitor-7 | Glutaminase C-IN-2 | Glutaminase-IN-4
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
