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- MedChemExpress(MCE)
- 美国
- HY-L0070V
- 2025年12月05日
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IDO Targeted Library
MCE 国际站：IDO Targeted Library
A unique library of 1,003 diverse compounds targeting IDO.
Description & Advantages:
• A unique library of 1,003 diverse compounds targeting IDO.
• Indoleamine 2,3-dioxygenase (IDO) is a heme-containing protein that catalyzes the oxidative cleavage of the C2−C3 double bond of the indole in tryptophan to provide N-formylkynurenine.
• IDO focused library designed by a combination of structure- and ligand-based methods.
• No PAINS (Pan Assay Interference Compounds), only medchem friendly compounds.
• Structurally diverse.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds can be readily followed with analogues either from stock or from new syntheses.
• Databases and compounds are provided by Enamine.
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文献和实验The Design, Annotation, and Application of a Kinase-Targeted Library
We present here a workflow for designing a kinase-targeted library (KTL) with the goal of capturing known kinase inhibitor chemical space. We validated our design retrospectively using recent, high-throughput screening data
Selection of Targeted Mutants from a Library of Randomly Mutagenized ES Cells
A method for random relatively unbiased mutagenesis of ES cells with a mutagenic retroviral vector is described. An orderly assembly of mutant ES cells in multi-well plates is generated. 3D pooling of the wells of the assembly allows quick
Application of QSAR and Shape Pharmacophore Modeling Approaches for Targeted Chemical Library Design
Optimization of chemical library composition affords more efficient identification of hits from biological screening experiments. The optimization could be achieved through rational selection of reagents used in combinatorial library
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