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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human SERPINC1 protein
- 亚型:
IgG1
- 保存条件:
Store at -20°C. Stable for one year after shipment.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
human, mouse, rat
- 保质期:
详见产品包装
- 库存:
充足
- 宿主:
Mouse
- 应用范围:
WB, IHC, IF/ICC, ELISA
- 靶点:
Serpin C1/Antithrombin III
- 抗体英文名:
Serpin C1/Antithrombin III Monoclonal antibody
- 抗体名:
Serpin C1/Antithrombin III Monoclonal antibody
- 规格:
50ul/100ul/150ul
| 规格: | 50ul | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥2200.0 |
| 规格: | 150ul | 产品价格: | ¥3000.0 |
经过测试的应用
| Positive WB detected in | human plasma, human brain tissue, human testis tissue, L02 cells, rat brain tissue |
| Positive IHC detected in | human liver cancer tissue, human liver tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells, L02 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:10000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:400-1:1600 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
66052-1-Ig targets Serpin C1/Antithrombin III in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IF/ICC, ELISA |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag9880 Product name: Recombinant human SERPINC1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-259 aa of BC022309 Sequence: MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| 别名 | Antithrombin III, Serpin C1, SERPINC1, 2B2E5, Antithrombin-III |
| 计算分子量 | 464 aa, 53 kDa |
| 观测分子量 | 53 kDa |
| GenBank蛋白编号 | BC022309 |
| 基因名称 | Serpin C1/Antithrombin III |
| Gene ID (NCBI) | 462 |
| RRID | AB_11042589 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P01008 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | IF | Matrix Biol Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility.Authors - Emna Ouni |
| mouse | WB | Front Oncol Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 geneAuthors - Jun Zhang |
| human | WB,IF | Orphanet J Rare Dis Clinical and functional characterization of p.Lys322stop variant in the SERPINC1 gene causing severe thrombophiliaAuthors - Haiyue Zhang |
化(diversification)在后生动物(Metazoon)进化早期即开始发生,通过基因的复制(duplication)和随后发生的偏离(divergence)产生了具有不同功能的多功能域结构。 第一节 免疫球蛋白超家族的组成和特点 一、Ig超家族的组成 由于细胞表面标志、单克隆抗体以及基因工程技术的应用,发现越来越多的膜表面分子和蛋白分子属于Ig超家族,主要包括T细胞、B细胞识别抗原受体及其信号转导分子,免疫球蛋白重链和轻链,MHC抗原及相关分子,免疫球蛋白Fc段受体,某些细胞因子受体,与神经
佚名 应用DNA序列分析和X晶体衍射分析等研究表明,许多细胞膜表面和机体某些蛋白质分子,其多肽链折叠方式与Ig折叠相似,在DNA水平和氨基酸序列上与IgV区或C区有较高的同源性,它们可能从同一原始祖先基因(primodial ancestral gene)经复制和突变衍生而来。编码这些多肽链的基因称为免疫球蛋白基因超家族(immunoglobulin gene
(divergence)产生了具有不同功能的多功能域结构。 第一节 免疫球蛋白超家族的组成和特点 一、Ig超家族的组成 由于细胞表面标志、单克隆抗体以及基因工程技术的应用,发现越来越多的膜表面分子和蛋白分子属于Ig超家族,主要包括T细胞、B细胞识别抗原受体及其信号转导分子,免疫球蛋白重链和轻链,MHC抗原及相关分子,免疫球蛋白Fc段受体,某些细胞因子受体,与神经系统功能和粘附有关的分子,某些粘附分子和分化抗原等(表3-1)。 表3-1 免疫球蛋白超家族的组成
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