- ￥1350 - 3000
- Proteintech
- 27792-1-AP
- 2025年10月13日
- WB, IHC, ELISA
- Rabbit
- human, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human OSM protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, ELISA
- 靶点：
Oncostatin M
- 抗体英文名：
Oncostatin M Polyclonal antibody
- 抗体名：
Oncostatin M Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | MCF-7 cells, Jurkat cells, rat testis tissue |
| Positive IHC detected in | human colon cancer tissue, human cervical cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
27792-1-AP targets Oncostatin M in WB, IHC, IF, ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, IHC, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag27093 Product name: Recombinant human OSM protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 26-221 aa of BC011589 Sequence: AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRR |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | oncostatin M |
| 别名 | OSM, Oncostatin-M |
| 计算分子量 | 252 aa, 28 kDa |
| 观测分子量 | 28 kDa |
| GenBank蛋白编号 | BC011589 |
| 基因名称 | OSM |
| Gene ID (NCBI) | 5008 |
| RRID | AB_2880974 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P13725 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Oncostatin M (OSM) is a multifunctional cytokine that belongs to the interleukin-6 (IL-6) family. It is primarily secreted by activated T lymphocytes and macrophages as a 28 kDa glycoprotein. OSM shares properties with all members of this cytokine family, but is most closely related in structure and function to leukemia inhibitory factor (LIF). OSM acts on a variety of cells and is involved in regulating gene activation, cell growth, and inflammatory processes. It is a potent inducer of anti-proteases, has anti-inflammatory properties, acts as an immune modifier, and promotes the deposition of extracellular matrix proteins . In the context of respiratory diseases, OSM may play a significant role in normal wound healing, as well as in remodeling and pathological fibrosis.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | IF | Jpn J Ophthalmol Role of oncostatin M in the pathogenesis of vernal keratoconjunctivitis: focus on tissue remodeling.Authors - Keitaro Mashimo |
| mouse | IHC | Int J Radiat Oncol Biol Phys Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in FibroblastAuthors - Peng Xu |
| human | WB,IHC | Neoplasia β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axisAuthors - Yijia Zhang |
Analysis Project 根据上传的数据类型从下拉菜单中选择新建一个分析项目。2、接着选择之前创建的特定测序项目。3、填写基因组组装的软件。4、成功创建分析项目之后，将看到以下窗口。点击链接进入 IMG/M 进行数据上传。你会获得一个分析项目编号 AP ID，根据提示选择测序数据的质量（完成图或草图）、拓扑（线型或者环状），并选择上传的 fasta 格式序列文件，最后点击 Summit 提交。可以查看数据分析的状态，分析结束后会自动返回 IMG/M 数据库专属的登录号，可以插入到你的文章里以方便读者
参与披网格蛋白小泡组装的一种蛋白质, 分子量为100kDa, 在披网格蛋白小泡组装中与受体的细胞质结构域相互作用, 起衔接作用。有两种类型衔接蛋白, AP1参与反面高尔基体的披网格蛋白小泡的组装, AP2则参与从细胞质膜形成的披网格蛋白的组装。 M6P受体蛋白既存在于反面高尔基体又存在于细胞质膜,所以这种受体既能同AP1作用又能与AP2相互作用。衔接蛋白AP2是一个二聚体,并且是由α衔接蛋白(α链)和β衔接蛋白(β链)两种衔接蛋白组成的异二聚体。 在酵母
-FGF-heparin sepharose complex was transferred in 60 µl 10 mM Tris pH 7.5, to a well of a microtiter plate containing 60 µl of 2« AP assay buffer (2 M diethanolamine, 1 mM MgCl2, 20 mM homoarginine, 12 mM p-nitrophenyl phosphate pH 9.5). The bound
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