相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
阿拉丁试剂,充足现货,稳定批间差Cytoscape 教程来了!快速实现顶刊同款通路网络图五大应用案例:Mustang Q 膜层析应用全解析1 个小工具,一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 免疫原:
Recombinant human TEK protein
- 亚型:
IgG
- 保存条件:
Store at -20°C. Stable for one year after shipment.
- 克隆性:
Polyclonal
- 标记物:
Unconjugated
- 适应物种:
human, mouse, rat
- 保质期:
详见产品包装
- 库存:
充足
- 宿主:
Rabbit
- 应用范围:
WB, IHC, IP, ELISA
- 靶点:
Tie-2/CD202b
- 抗体英文名:
Tie-2/CD202b Polyclonal antibody
- 抗体名:
Tie-2/CD202b Polyclonal antibody
- 规格:
50ul/100ul/150ul
| 规格: | 50ul | 产品价格: | ¥1350.0 |
|---|---|---|---|
| 规格: | 100ul | 产品价格: | ¥2200.0 |
| 规格: | 150ul | 产品价格: | ¥3000.0 |
经过测试的应用
| Positive WB detected in | mouse lung tissue, mouse liver tissue, Rat lung tissue |
| Positive IP detected in | mouse lung tissue |
| Positive IHC detected in | human placenta tissue, mouse kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:1000-1:4000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
19157-1-AP targets Tie-2/CD202b in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IP, ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag13523 Product name: Recombinant human TEK protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 779-1124 aa of BC035514 Sequence: RRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSHHLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | TEK tyrosine kinase, endothelial |
| 别名 | TEK, Angiopoietin 1 receptor, Angiopoietin-1 receptor, CD202B, EC:2.7.10.1 |
| 计算分子量 | 1124 aa, 126 kDa |
| 观测分子量 | 140 kDa |
| GenBank蛋白编号 | BC035514 |
| 基因名称 | Tie2 |
| Gene ID (NCBI) | 7010 |
| RRID | AB_10644297 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q02763 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Tie2 (also known as TEK) is a tyrosine-protein kinase expressed almost exclusively on endothelial cells. It contains two immunoglobulin-like domains, three epidermal growth factor (EGF)--like domains and three fibronectin type III repeats. Tie2 acts as a cell-surface receptor for ANGPT1, ANGPT2, and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Mutations in the gene Tie2 are associated with inherited venous malformations of the skin and mucous membranes. Human Tie2 has a calculated molecular weight of 126 kDa. As a result of glycosylation, the apparent molecular mass of Tie2 is approximately 140-160 kDa.
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
- 作者
- 内容
- 询问日期
文献和实验细胞激活;④通过转基因表达CD40L的成纤维细胞。也能刺激B细胞;⑤CD40或CD40L基因敲除的小鼠,抗体产生形成的缺陷类似人类的X性联高IgM血症,患者只产生了IgM,而无其他类别的抗体,也无生发中心,抗感染能力明显下降。 CD40与其配体CD401。的结合,导致CD40分子的寡聚化,使胞质中的TNF受体相关因子(TNF receptor-associ-atedfactor,TRAF)与CD40的胞内结构域结合。TRAF参与启动的酶催化级联反应,最终导致转录因子NFκB和AP-1等活化。
。 关键数据: 膜蛋白成功转移:Western blot证实NANO-AP39-PM保留了血小板特征膜蛋白(GPIbα、GPVI、CD42α、CD47),赋予其血栓靶向能力(图1J)。 靶向性验证:活体成像显示NANO-AP39-PM在损伤血管处的蓄积量是未包膜NANO-AP39的3.1倍,且损伤组荧光强度是假手术组的4.7倍(图5E)。 治疗效果:单次注射NANO-AP39-PM后,7/11个肿瘤被完全消除;在自体肝癌模型中,治疗组小鼠100天存活率达100%,而对照组第23天全部死亡。 核心
CUSABIO季度文献盘点:二季度新增600篇产品引用文献,总文献数量已达 31400篇!
-1β ELISA Kit; CSB-E08054m 研究亮点 银屑病皮损中PRELP表达下调,IL-17A通过STAT3直接抑制PRELP转录。PRELP可抑制角质形成细胞增殖、促进凋亡,并阻断NF-κB/MAPK通路,减少炎症因子及IL-6/IL-23/IL-1β分泌,从而抑制Th17分化。过表达PRELP可减轻小鼠银屑病样皮炎,提示其作为IL-17A通路内源性负调控因子的治疗潜力。 02 标题:Myeloid Mas drives
技术资料暂无技术资料 索取技术资料











