- ￥1350 - 3000
- Proteintech
- 13356-1-AP
- 2026年05月21日
- WB, ELISA
- Rabbit
- human, mouse, rat
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human IL-10RA protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
IL-10RA
- 抗体英文名：
IL-10RA Polyclonal antibody
- 抗体名：
IL-10RA Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | HeLa cells, human heart tissue, human placenta tissue, human liver tissue, K-562 cells, mouse brain tissue, rat brain tissue, rat liver tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
13356-1-AP targets IL-10RA in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag4156 Product name: Recombinant human IL-10RA protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 253-578 aa of BC028082 Sequence: CLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNGEPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | interleukin 10 receptor, alpha |
| 别名 | CD210, CDw210a, HIL 10R, IL 10 receptor subunit alpha, IL 10R subunit 1, IL 10R subunit alpha, IL 10R1, IL 10RA, IL-10 R alpha, IL10R, IL10RA, IL-10RA, interleukin 10 receptor, alpha |
| 计算分子量 | 578 aa, 63 kDa |
| 观测分子量 | 70-72 kDa, 90-95 kDa |
| GenBank蛋白编号 | BC028082 |
| 基因名称 | IL-10RA |
| Gene ID (NCBI) | 3587 |
| RRID | AB_10643390 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q13651 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in maintaining immune system balance. IL-10 signals through a receptor complex consisting of two molecules of the IL-10R alpha-chain (IL-10RA) and two molecules of the accessory IL-10R beta-chain (IL-10RB) (PMID: 22236434). IL-10RA and IL-10RB are members of the type II cytokine receptor family. IL-10RA, also known as IL-10R1 or CD210, is expressed on most hematopoietic cells at a basal level but is upregulated by various cells upon activation (PMID: 24507158). IL-10RA serves as the ligand-binding subunit of the receptor complex. Upon binding of IL-10 to the IL-10R complex, the kinases JAK1 and TYK2 are activated and catalyze the phosphorylation of IL-10RA at specific intracellular tyrosine residues, leading to the recruitment and subsequent phosphorylation of STAT3 (PMID: 11244051; 10433356).
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验| Species | Application | Title |
|---|---|---|
| mouse | IF | Front Immunol The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathyAuthors - Yanli Ma |
| human,mouse | WB,IF | Adv Sci (Weinh) Functionalized Biomimetic Nanoparticles Targeting the IL-10/IL-10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in OsteoarthritisAuthors - Wenwei Li
|
信号；⑤进一步活化的T细胞更多表达CD401。和分泌细胞因子，其中较重要的如IL-4。与B细胞表面的IL-4R结合．促使B细胞进一步活化并开始增殖分化。参与B激活的其他分子还包括CD30与CD30L(CDl53)、41BB与41BBL、B7-RP与ICOS等，细胞因子IL-5和II．-6则在B细胞激活的后期发挥作用。 图10-7 T细胞与B细胞之间的相互作用图中圆圈内由文字代表第二信号；注意最终生成的抗体是针对抗原B表位(绿色)而非T表位(红色)。2.T、B细胞相互作用的特异性 需要指出
CUSABIO季度文献盘点：二季度新增600篇产品引用文献，总文献数量已达 31400篇！
mMouse Interleukin 4,IL-4 ELISA KIT; CSB-E04634mMouse interleukin 10,IL-10 ELISA KIT; CSB-E04594mMouse Platelet Factor 4,PF-4 ELISA Kit; CSB-E07884m 研究亮点 本文证实急性胰腺炎（AP）患者肠道多形拟杆菌丰度下降，会诱导 PF4⁺巨噬细胞浸润，经 PF4-CCR1 通路招募中性粒细胞、Th2 细胞，诱发 SIRS/CARS 免疫失衡；多形拟杆菌上调肠 NNMT 提升 1MNA
tanbo110 1：Mda-7/IL-24基因是不是就是MDA-7翻译后得IL-24蛋白啊？ 2：MDA-D-74基因我查了GENBANK为什么查不到呢？HUMO的 我看了最近看了篇 Cloning and characterization of SARI (suppressor of AP-1, Regulated by IFN). 的问题 hanyanyan1015 我也查不到，到底
技术资料暂无技术资料 索取技术资料
